CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance

Signal transduction induced by chimeric antigen receptors (CARs) is generally believed to rely on the activity of the SRC family kinase (SFK) LCK, as is the case with T cell receptor (TCR) signaling. Here, we show that CAR signaling occurs in the absence of LCK. This LCK-independent signaling requir...

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Detalles Bibliográficos
Autores principales: Wu, Ling, Brzostek, Joanna, Sakthi Vale, Previtha Dawn, Wei, Qianru, Koh, Clara K.T., Ong, June Xu Hui, Wu, Liang-zhe, Tan, Jia Chi, Chua, Yen Leong, Yap, Jiawei, Song, Yuan, Tan, Vivian Jia Yi, Tan, Triscilla Y.Y., Lai, Junyun, MacAry, Paul A., Gascoigne, Nicholas R.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975250/
https://www.ncbi.nlm.nih.gov/pubmed/36696897
http://dx.doi.org/10.1016/j.xcrm.2023.100917

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