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Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975287/ https://www.ncbi.nlm.nih.gov/pubmed/36874750 http://dx.doi.org/10.7759/cureus.34357 |
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author | Khalid, Sameeha Laput, Gieric Khorfan, Kamal Roytman, Marina |
author_facet | Khalid, Sameeha Laput, Gieric Khorfan, Kamal Roytman, Marina |
author_sort | Khalid, Sameeha |
collection | PubMed |
description | Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We present three cases of patients who developed hepatic and bile duct malignancies in the setting of AAS use and testosterone supplementation, arising from a single tertiary referral center. Additionally, we review the literature for the mechanisms behind the possible androgen-mediated malignant transformation of these liver and bile duct tumors. |
format | Online Article Text |
id | pubmed-9975287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-99752872023-03-02 Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use Khalid, Sameeha Laput, Gieric Khorfan, Kamal Roytman, Marina Cureus Gastroenterology Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We present three cases of patients who developed hepatic and bile duct malignancies in the setting of AAS use and testosterone supplementation, arising from a single tertiary referral center. Additionally, we review the literature for the mechanisms behind the possible androgen-mediated malignant transformation of these liver and bile duct tumors. Cureus 2023-01-29 /pmc/articles/PMC9975287/ /pubmed/36874750 http://dx.doi.org/10.7759/cureus.34357 Text en Copyright © 2023, Khalid et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Gastroenterology Khalid, Sameeha Laput, Gieric Khorfan, Kamal Roytman, Marina Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title | Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title_full | Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title_fullStr | Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title_full_unstemmed | Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title_short | Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use |
title_sort | development of liver cancers as an unexpected consequence of anabolic androgenic steroid use |
topic | Gastroenterology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975287/ https://www.ncbi.nlm.nih.gov/pubmed/36874750 http://dx.doi.org/10.7759/cureus.34357 |
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