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Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use

Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We p...

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Detalles Bibliográficos
Autores principales: Khalid, Sameeha, Laput, Gieric, Khorfan, Kamal, Roytman, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975287/
https://www.ncbi.nlm.nih.gov/pubmed/36874750
http://dx.doi.org/10.7759/cureus.34357
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author Khalid, Sameeha
Laput, Gieric
Khorfan, Kamal
Roytman, Marina
author_facet Khalid, Sameeha
Laput, Gieric
Khorfan, Kamal
Roytman, Marina
author_sort Khalid, Sameeha
collection PubMed
description Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We present three cases of patients who developed hepatic and bile duct malignancies in the setting of AAS use and testosterone supplementation, arising from a single tertiary referral center. Additionally, we review the literature for the mechanisms behind the possible androgen-mediated malignant transformation of these liver and bile duct tumors.
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spelling pubmed-99752872023-03-02 Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use Khalid, Sameeha Laput, Gieric Khorfan, Kamal Roytman, Marina Cureus Gastroenterology Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We present three cases of patients who developed hepatic and bile duct malignancies in the setting of AAS use and testosterone supplementation, arising from a single tertiary referral center. Additionally, we review the literature for the mechanisms behind the possible androgen-mediated malignant transformation of these liver and bile duct tumors. Cureus 2023-01-29 /pmc/articles/PMC9975287/ /pubmed/36874750 http://dx.doi.org/10.7759/cureus.34357 Text en Copyright © 2023, Khalid et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Khalid, Sameeha
Laput, Gieric
Khorfan, Kamal
Roytman, Marina
Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title_full Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title_fullStr Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title_full_unstemmed Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title_short Development of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid Use
title_sort development of liver cancers as an unexpected consequence of anabolic androgenic steroid use
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975287/
https://www.ncbi.nlm.nih.gov/pubmed/36874750
http://dx.doi.org/10.7759/cureus.34357
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