Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer

Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal PCa. Through genomic and transcriptomic analysis of patient dataset...

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Detalles Bibliográficos
Autores principales: Dhital, Brittiny, Santasusagna, Sandra, Kirthika, Perumalraja, Xu, Michael, Li, Peiyao, Carceles-Cordon, Marc, Soni, Rajesh K., Li, Zhuoning, Hendrickson, Ronald C., Schiewer, Matthew J., Kelly, William K., Sternberg, Cora N., Luo, Jun, Lujambio, Amaia, Cordon-Cardo, Carlos, Alvarez-Fernandez, Monica, Malumbres, Marcos, Huang, Haojie, Ertel, Adam, Domingo-Domenech, Josep, Rodriguez-Bravo, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975292/
https://www.ncbi.nlm.nih.gov/pubmed/36787737
http://dx.doi.org/10.1016/j.xcrm.2023.100937

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