With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors

Mutation-selective KRAS inhibitors are revolutionizing the treatment of RAS-mutant tumors but cannot achieve durable effects alone. Kemp and colleagues(1) recently showed how the KRAS-G12D-specific inhibitor MRTX1133, while impairing cancer proliferation, stimulates T cell infiltration, which is cru...

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Detalles Bibliográficos
Autor principal: Mainardi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975326/
https://www.ncbi.nlm.nih.gov/pubmed/36812887
http://dx.doi.org/10.1016/j.xcrm.2023.100950
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author Mainardi, Sara
author_facet Mainardi, Sara
author_sort Mainardi, Sara
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description Mutation-selective KRAS inhibitors are revolutionizing the treatment of RAS-mutant tumors but cannot achieve durable effects alone. Kemp and colleagues(1) recently showed how the KRAS-G12D-specific inhibitor MRTX1133, while impairing cancer proliferation, stimulates T cell infiltration, which is crucial for sustained disease control.
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spelling pubmed-99753262023-03-02 With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors Mainardi, Sara Cell Rep Med Spotlight Mutation-selective KRAS inhibitors are revolutionizing the treatment of RAS-mutant tumors but cannot achieve durable effects alone. Kemp and colleagues(1) recently showed how the KRAS-G12D-specific inhibitor MRTX1133, while impairing cancer proliferation, stimulates T cell infiltration, which is crucial for sustained disease control. Elsevier 2023-02-21 /pmc/articles/PMC9975326/ /pubmed/36812887 http://dx.doi.org/10.1016/j.xcrm.2023.100950 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Mainardi, Sara
With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title_full With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title_fullStr With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title_full_unstemmed With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title_short With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
title_sort with a little help from my t friends: t cells increase efficacy of kras (g12d) inhibitors
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975326/
https://www.ncbi.nlm.nih.gov/pubmed/36812887
http://dx.doi.org/10.1016/j.xcrm.2023.100950
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