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With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors
Mutation-selective KRAS inhibitors are revolutionizing the treatment of RAS-mutant tumors but cannot achieve durable effects alone. Kemp and colleagues(1) recently showed how the KRAS-G12D-specific inhibitor MRTX1133, while impairing cancer proliferation, stimulates T cell infiltration, which is cru...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975326/ https://www.ncbi.nlm.nih.gov/pubmed/36812887 http://dx.doi.org/10.1016/j.xcrm.2023.100950 |