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Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The d...

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Autores principales: Zhou, Yujuan, Wang, Xu, Liu, Yingying, Gu, Yulu, Gu, Renjun, Zhang, Geng, Lin, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975352/
https://www.ncbi.nlm.nih.gov/pubmed/36875663
http://dx.doi.org/10.3389/fnins.2023.1125376
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author Zhou, Yujuan
Wang, Xu
Liu, Yingying
Gu, Yulu
Gu, Renjun
Zhang, Geng
Lin, Qing
author_facet Zhou, Yujuan
Wang, Xu
Liu, Yingying
Gu, Yulu
Gu, Renjun
Zhang, Geng
Lin, Qing
author_sort Zhou, Yujuan
collection PubMed
description Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD.
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spelling pubmed-99753522023-03-02 Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease Zhou, Yujuan Wang, Xu Liu, Yingying Gu, Yulu Gu, Renjun Zhang, Geng Lin, Qing Front Neurosci Neuroscience Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD. Frontiers Media S.A. 2023-02-15 /pmc/articles/PMC9975352/ /pubmed/36875663 http://dx.doi.org/10.3389/fnins.2023.1125376 Text en Copyright © 2023 Zhou, Wang, Liu, Gu, Gu, Zhang and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhou, Yujuan
Wang, Xu
Liu, Yingying
Gu, Yulu
Gu, Renjun
Zhang, Geng
Lin, Qing
Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title_full Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title_fullStr Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title_full_unstemmed Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title_short Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
title_sort mechanisms of abnormal adult hippocampal neurogenesis in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975352/
https://www.ncbi.nlm.nih.gov/pubmed/36875663
http://dx.doi.org/10.3389/fnins.2023.1125376
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