TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response....

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Detalles Bibliográficos
Autores principales: Xiao, Tengfei, Sun, Mingzhong, Zhao, Chuanxiang, Kang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975512/
https://www.ncbi.nlm.nih.gov/pubmed/36874007
http://dx.doi.org/10.3389/fphar.2023.1037925
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author Xiao, Tengfei
Sun, Mingzhong
Zhao, Chuanxiang
Kang, Jingjing
author_facet Xiao, Tengfei
Sun, Mingzhong
Zhao, Chuanxiang
Kang, Jingjing
author_sort Xiao, Tengfei
collection PubMed
description TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.
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spelling pubmed-99755122023-03-02 TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases Xiao, Tengfei Sun, Mingzhong Zhao, Chuanxiang Kang, Jingjing Front Pharmacol Pharmacology TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases. Frontiers Media S.A. 2023-02-15 /pmc/articles/PMC9975512/ /pubmed/36874007 http://dx.doi.org/10.3389/fphar.2023.1037925 Text en Copyright © 2023 Xiao, Sun, Zhao and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xiao, Tengfei
Sun, Mingzhong
Zhao, Chuanxiang
Kang, Jingjing
TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title_full TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title_fullStr TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title_full_unstemmed TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title_short TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases
title_sort trpv1: a promising therapeutic target for skin aging and inflammatory skin diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975512/
https://www.ncbi.nlm.nih.gov/pubmed/36874007
http://dx.doi.org/10.3389/fphar.2023.1037925
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