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Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes
Pancreatic β-cell function impairment and insulin resistance are central to the development of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical treatment approach to treat morbid obesity and achieve lasting T2DM remission. Traditionally, sustained postoperative...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975540/ https://www.ncbi.nlm.nih.gov/pubmed/36875493 http://dx.doi.org/10.3389/fendo.2023.1031610 |
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author | Liu, Tiantong Zou, Xi Ruze, Rexiati Xu, Qiang |
author_facet | Liu, Tiantong Zou, Xi Ruze, Rexiati Xu, Qiang |
author_sort | Liu, Tiantong |
collection | PubMed |
description | Pancreatic β-cell function impairment and insulin resistance are central to the development of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical treatment approach to treat morbid obesity and achieve lasting T2DM remission. Traditionally, sustained postoperative glycemic control was considered a direct result of decreased nutrient intake and weight loss. However, mounting evidence in recent years implicated a weight-independent mechanism that involves pancreatic islet reconstruction and improved β-cell function. In this article, we summarize the role of β-cell in the pathogenesis of T2DM, review recent research progress focusing on the impact of Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) on pancreatic β-cell pathophysiology, and finally discuss therapeutics that have the potential to assist in the treatment effect of surgery and prevent T2D relapse. |
format | Online Article Text |
id | pubmed-9975540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99755402023-03-02 Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes Liu, Tiantong Zou, Xi Ruze, Rexiati Xu, Qiang Front Endocrinol (Lausanne) Endocrinology Pancreatic β-cell function impairment and insulin resistance are central to the development of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical treatment approach to treat morbid obesity and achieve lasting T2DM remission. Traditionally, sustained postoperative glycemic control was considered a direct result of decreased nutrient intake and weight loss. However, mounting evidence in recent years implicated a weight-independent mechanism that involves pancreatic islet reconstruction and improved β-cell function. In this article, we summarize the role of β-cell in the pathogenesis of T2DM, review recent research progress focusing on the impact of Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) on pancreatic β-cell pathophysiology, and finally discuss therapeutics that have the potential to assist in the treatment effect of surgery and prevent T2D relapse. Frontiers Media S.A. 2023-02-15 /pmc/articles/PMC9975540/ /pubmed/36875493 http://dx.doi.org/10.3389/fendo.2023.1031610 Text en Copyright © 2023 Liu, Zou, Ruze and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Liu, Tiantong Zou, Xi Ruze, Rexiati Xu, Qiang Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title | Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title_full | Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title_fullStr | Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title_full_unstemmed | Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title_short | Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes |
title_sort | bariatric surgery: targeting pancreatic β cells to treat type ii diabetes |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975540/ https://www.ncbi.nlm.nih.gov/pubmed/36875493 http://dx.doi.org/10.3389/fendo.2023.1031610 |
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