Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

Abdominal aortic aneurysm (AAA) is a progressive aortic dilatation, causing ∼80% mortality upon rupture. Currently, there is no approved drug therapy for AAA. Surgical repairs are invasive and risky and thus not recommended to patients with small AAAs which, however, account for ∼90% of the newly di...

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Detalles Bibliográficos
Autores principales: Yodsanit, Nisakorn, Shirasu, Takuro, Huang, Yitao, Yin, Li, Islam, Zain Husain, Gregg, Alexander Christopher, Riccio, Alessandra Marie, Tang, Runze, Kent, Eric William, Wang, Yuyuan, Xie, Ruosen, Zhao, Yi, Ye, Mingzhou, Zhu, Jingcheng, Huang, Yi, Hoyt, Nicholas, Zhang, Mengxue, Hossack, John A., Salmon, Morgan, Kent, K. Craig, Guo, Lian-Wang, Gong, Shaoqin, Wang, Bowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975632/
https://www.ncbi.nlm.nih.gov/pubmed/36875050
http://dx.doi.org/10.1016/j.bioactmat.2023.02.009

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