Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is often found mutated, resulting in the addition of a nuclear export signal and a shift of the protein to the cytoplasm (NP...

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Detalles Bibliográficos
Autores principales: Wang, Xue Qing David, Fan, Dandan, Han, Qinyu, Liu, Yiman, Miao, Hongzhi, Wang, Xinyu, Li, Qinglan, Chen, Dong, Gore, Haley, Himadewi, Pamela, Pfeifer, Gerd P., Cierpicki, Tomasz, Grembecka, Jolanta, Su, Jianzhong, Chong, Shasha, Wan, Liling, Zhang, Xiaotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975662/
https://www.ncbi.nlm.nih.gov/pubmed/36455589
http://dx.doi.org/10.1158/2159-8290.CD-22-0424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975662/
https://www.ncbi.nlm.nih.gov/pubmed/36455589
http://dx.doi.org/10.1158/2159-8290.CD-22-0424

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