Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis

Low hypodiploidy defines a rare subtype of B-cell acute lymphoblastic leukemia (B-ALL) with a dismal outcome. To investigate the genomic basis of low-hypodiploid ALL (LH-ALL) in adults, we analyzed copy-number aberrations, loss of heterozygosity, mutations, and cytogenetics data in a prospective coh...

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Detalles Bibliográficos
Autores principales: Kim, Rathana, Bergugnat, Hugo, Larcher, Lise, Duchmann, Matthieu, Passet, Marie, Gachet, Stéphanie, Cuccuini, Wendy, Lafage-Pochitaloff, Marina, Pastoret, Cédric, Grardel, Nathalie, Asnafi, Vahid, Schäfer, Beat W., Delabesse, Eric, Itzykson, Raphaël, Adès, Lionel, Hicheri, Yosr, Chalandon, Yves, Graux, Carlos, Chevallier, Patrice, Hunault, Mathilde, Leguay, Thibaut, Huguet, Françoise, Lhéritier, Véronique, Dombret, Hervé, Soulier, Jean, Rousselot, Philippe, Boissel, Nicolas, Clappier, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975768/
https://www.ncbi.nlm.nih.gov/pubmed/36630200
http://dx.doi.org/10.1158/2643-3230.BCD-22-0154

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