The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80

CTLA‐4 and PD‐1 are key immune checkpoint receptors that are targeted in the treatment of cancer. A recently identified physical interaction between the respective ligands, CD80 and PD‐L1, has been shown to block PD‐L1/PD‐1 binding and to prevent PD‐L1 inhibitory functions. Since CTLA‐4 is known to...

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Detalles Bibliográficos
Autores principales: Kennedy, Alan, Robinson, Maximillian A, Hinze, Claudia, Waters, Erin, Williams, Cayman, Halliday, Neil, Dovedi, Simon, Sansom, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975936/
https://www.ncbi.nlm.nih.gov/pubmed/36727298
http://dx.doi.org/10.15252/embj.2022111556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975936/
https://www.ncbi.nlm.nih.gov/pubmed/36727298
http://dx.doi.org/10.15252/embj.2022111556

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