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The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80

CTLA‐4 and PD‐1 are key immune checkpoint receptors that are targeted in the treatment of cancer. A recently identified physical interaction between the respective ligands, CD80 and PD‐L1, has been shown to block PD‐L1/PD‐1 binding and to prevent PD‐L1 inhibitory functions. Since CTLA‐4 is known to...

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Detalles Bibliográficos
Autores principales:	Kennedy, Alan, Robinson, Maximillian A, Hinze, Claudia, Waters, Erin, Williams, Cayman, Halliday, Neil, Dovedi, Simon, Sansom, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975936/ https://www.ncbi.nlm.nih.gov/pubmed/36727298 http://dx.doi.org/10.15252/embj.2022111556

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