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Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan

OBJECTIVE: Data regarding diabetic ketoacidosis (DKA) at diagnosis of type one diabetes (T1D) in developing countries are scarce. The aim of this study was to describe the frequency of DKA at the onset of T1D in children and adolescents in Jordan and to compare the clinical and biochemical character...

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Autores principales: Odeh, Rasha, Gharaibeh, Lobna, Daher, Amirah, Albaramki, Jumana, Ashour, Bahaa, Barakat, Fatima Al, Dahabreh, Dina, Hadadin, Hiba, Melhem, Tala, Alassaf, Abeer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976172/
https://www.ncbi.nlm.nih.gov/pubmed/36264035
http://dx.doi.org/10.4274/jcrpe.galenos.2022.2022-5-8
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author Odeh, Rasha
Gharaibeh, Lobna
Daher, Amirah
Albaramki, Jumana
Ashour, Bahaa
Barakat, Fatima Al
Dahabreh, Dina
Hadadin, Hiba
Melhem, Tala
Alassaf, Abeer
author_facet Odeh, Rasha
Gharaibeh, Lobna
Daher, Amirah
Albaramki, Jumana
Ashour, Bahaa
Barakat, Fatima Al
Dahabreh, Dina
Hadadin, Hiba
Melhem, Tala
Alassaf, Abeer
author_sort Odeh, Rasha
collection PubMed
description OBJECTIVE: Data regarding diabetic ketoacidosis (DKA) at diagnosis of type one diabetes (T1D) in developing countries are scarce. The aim of this study was to describe the frequency of DKA at the onset of T1D in children and adolescents in Jordan and to compare the clinical and biochemical characteristics between the group that presented with DKA and the group that did not. METHODS: The records of 341 children and adolescents, less than sixteen years of age, who were diagnosed with T1D between 2015 and 2019 were evaluated retrospectively. RESULTS: Of all the children diagnosed with T1D, 108 (31.7%) presented with DKA. The majority had mild or moderate DKA (38% and 33.3% respectively). Higher paternal education levels were associated with a lower probability of presenting with DKA (p=0.043). A family history of T1D had a protective effect on the occurrence of DKA (Odds ratio=2.138; 95% confidence interval=1.167-3.917, p=0.014). Patients with celiac disease and higher HbA1c levels were more likely to experience recurrent episodes of DKA, (p=0.004 and 0.011, respectively). CONCLUSION: In Jordan, the rate of DKA at presentation of T1D remains high. Prevention campaigns are needed to increase diabetes awareness among the public and healthcare providers.
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spelling pubmed-99761722023-03-02 Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan Odeh, Rasha Gharaibeh, Lobna Daher, Amirah Albaramki, Jumana Ashour, Bahaa Barakat, Fatima Al Dahabreh, Dina Hadadin, Hiba Melhem, Tala Alassaf, Abeer J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Data regarding diabetic ketoacidosis (DKA) at diagnosis of type one diabetes (T1D) in developing countries are scarce. The aim of this study was to describe the frequency of DKA at the onset of T1D in children and adolescents in Jordan and to compare the clinical and biochemical characteristics between the group that presented with DKA and the group that did not. METHODS: The records of 341 children and adolescents, less than sixteen years of age, who were diagnosed with T1D between 2015 and 2019 were evaluated retrospectively. RESULTS: Of all the children diagnosed with T1D, 108 (31.7%) presented with DKA. The majority had mild or moderate DKA (38% and 33.3% respectively). Higher paternal education levels were associated with a lower probability of presenting with DKA (p=0.043). A family history of T1D had a protective effect on the occurrence of DKA (Odds ratio=2.138; 95% confidence interval=1.167-3.917, p=0.014). Patients with celiac disease and higher HbA1c levels were more likely to experience recurrent episodes of DKA, (p=0.004 and 0.011, respectively). CONCLUSION: In Jordan, the rate of DKA at presentation of T1D remains high. Prevention campaigns are needed to increase diabetes awareness among the public and healthcare providers. Galenos Publishing 2023-03 2023-02-27 /pmc/articles/PMC9976172/ /pubmed/36264035 http://dx.doi.org/10.4274/jcrpe.galenos.2022.2022-5-8 Text en ©Copyright 2023 by Turkish Pediatric Endocrinology and Diabetes Society | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Odeh, Rasha
Gharaibeh, Lobna
Daher, Amirah
Albaramki, Jumana
Ashour, Bahaa
Barakat, Fatima Al
Dahabreh, Dina
Hadadin, Hiba
Melhem, Tala
Alassaf, Abeer
Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title_full Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title_fullStr Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title_full_unstemmed Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title_short Frequency, Clinical Characteristics and Predictors of Ketoacidosis at Diagnosis of Type One Diabetes Mellitus in Children and Adolescents from Jordan
title_sort frequency, clinical characteristics and predictors of ketoacidosis at diagnosis of type one diabetes mellitus in children and adolescents from jordan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976172/
https://www.ncbi.nlm.nih.gov/pubmed/36264035
http://dx.doi.org/10.4274/jcrpe.galenos.2022.2022-5-8
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