Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents

[Image: see text] Targeted covalent inhibitors hold promise for drug discovery, particularly for kinases. Targeting the catalytic lysine of epidermal growth factor receptor (EGFR) has attracted attention as a new strategy to overcome resistance due to the emergence of C797S mutation. Sulfonyl fluori...

Descripción completa

Detalles Bibliográficos
Autores principales: Arafet, Kemel, Scalvini, Laura, Galvani, Francesca, Martí, Sergio, Moliner, Vicent, Mor, Marco, Lodola, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976278/
https://www.ncbi.nlm.nih.gov/pubmed/36762429
http://dx.doi.org/10.1021/acs.jcim.2c01586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976278/
https://www.ncbi.nlm.nih.gov/pubmed/36762429
http://dx.doi.org/10.1021/acs.jcim.2c01586

Ejemplares similares