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pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin
This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, resp...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976327/ https://www.ncbi.nlm.nih.gov/pubmed/36873513 http://dx.doi.org/10.1016/j.heliyon.2023.e13705 |
Sumario: | This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH(2)-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH(2)-SBA-16@IMC@GA were synthesized by wrapping the NH(2)-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N(2) adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH(2)-SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin. |
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