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Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer

Curcumin, a natural organic component obtained from Curcuma longa’s rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from scholars worldwide. Numerous studies have reporte...

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Autores principales: Liu, Xiaoping, Qi, Mingming, Li, Xidie, Wang, Jingjin, Wang, Mingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976389/
https://www.ncbi.nlm.nih.gov/pubmed/36859398
http://dx.doi.org/10.1186/s13048-023-01120-6
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author Liu, Xiaoping
Qi, Mingming
Li, Xidie
Wang, Jingjin
Wang, Mingyuan
author_facet Liu, Xiaoping
Qi, Mingming
Li, Xidie
Wang, Jingjin
Wang, Mingyuan
author_sort Liu, Xiaoping
collection PubMed
description Curcumin, a natural organic component obtained from Curcuma longa’s rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from scholars worldwide. Numerous studies have reported that curcumin can delay ovarian cancer (OC), increase its sensitivity to chemotherapy, and reduce chemotherapy drugs’ side effects. It has been shown considerable anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumor metastasis, and regulating enzyme activity. With an in-depth study of curcumin’s anti-OC mechanism, its clinical application will have broader prospects. This review summarizes the latest studies on curcumin’s anti-OC activities, and discusses the specific mechanism, hoping to provide references for further research and applications.
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spelling pubmed-99763892023-03-02 Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer Liu, Xiaoping Qi, Mingming Li, Xidie Wang, Jingjin Wang, Mingyuan J Ovarian Res Review Curcumin, a natural organic component obtained from Curcuma longa’s rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from scholars worldwide. Numerous studies have reported that curcumin can delay ovarian cancer (OC), increase its sensitivity to chemotherapy, and reduce chemotherapy drugs’ side effects. It has been shown considerable anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumor metastasis, and regulating enzyme activity. With an in-depth study of curcumin’s anti-OC mechanism, its clinical application will have broader prospects. This review summarizes the latest studies on curcumin’s anti-OC activities, and discusses the specific mechanism, hoping to provide references for further research and applications. BioMed Central 2023-03-01 /pmc/articles/PMC9976389/ /pubmed/36859398 http://dx.doi.org/10.1186/s13048-023-01120-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Xiaoping
Qi, Mingming
Li, Xidie
Wang, Jingjin
Wang, Mingyuan
Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title_full Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title_fullStr Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title_full_unstemmed Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title_short Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
title_sort curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976389/
https://www.ncbi.nlm.nih.gov/pubmed/36859398
http://dx.doi.org/10.1186/s13048-023-01120-6
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