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Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

BACKGROUND: Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and multiple non-steroidal anti-inflammatory drugs (NSAIDs). A global map of CYP2C9 variability...

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Detalles Bibliográficos
Autores principales:	Zhou, Yitian, Nevosadová, Lenka, Eliasson, Erik, Lauschke, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976394/ https://www.ncbi.nlm.nih.gov/pubmed/36855170 http://dx.doi.org/10.1186/s40246-023-00461-z

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