Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase η and reduces DNA synthesis fidelity

DNA polymerases catalyze DNA synthesis with high efficiency, which is essential for all life. Extensive kinetic and structural efforts have been executed in exploring mechanisms of DNA polymerases, surrounding their kinetic pathway, catalytic mechanisms, and factors that dictate polymerase fidelity....

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Detalles Bibliográficos
Autores principales: Chang, Caleb, Lee Luo, Christie, Eleraky, Sarah, Lin, Aaron, Zhou, Grace, Gao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976465/
https://www.ncbi.nlm.nih.gov/pubmed/36702254
http://dx.doi.org/10.1016/j.jbc.2023.102938

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