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Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates
BACKGROUND: Changes of serum lipoprotein concentration during bacteremia or sepsis are observed and lipoproteins concentration facilitate the evaluation severity of sepsis in adults, but its clinical usage is still unclear. Here, we analyzed the lipoprotein concentration in neonates with sepsis and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976484/ https://www.ncbi.nlm.nih.gov/pubmed/36855137 http://dx.doi.org/10.1186/s40001-023-01077-8 |
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author | Guo, Junfei Lai, Weiming Wu, Yongbing Li, Huan Fu, Zhenhua Mu, Xiaoping |
author_facet | Guo, Junfei Lai, Weiming Wu, Yongbing Li, Huan Fu, Zhenhua Mu, Xiaoping |
author_sort | Guo, Junfei |
collection | PubMed |
description | BACKGROUND: Changes of serum lipoprotein concentration during bacteremia or sepsis are observed and lipoproteins concentration facilitate the evaluation severity of sepsis in adults, but its clinical usage is still unclear. Here, we analyzed the lipoprotein concentration in neonates with sepsis and discussed its use in stratifying patients. METHODS: This is a retrospective study involved 88 culture-proven septic patients. Clinical and microbiology data of involved patients were collected via inquiring databases of our institute. Patients were grouped according to blood culture results or procalcitonin level; the difference between groups were analyzed. RESULTS: Compared with uninfected group, there is no change of triglyceride (TG) concentrations and significant decrease of Total cholesterol (TC) concentration in septic patients. There is no significant difference between Gram-positive and Gram-negative-related septic patients in terms of serum TG and TC concentration. Other than group with procalcitonin level of 0.5–2 ng/ml, both serum TG and TC concentration were decreased while serum procalcitonin level increasing. CONCLUSIONS: Our results indicated that serum lipoprotein concentration may be recommended to help diagnosis of bacteria and to evaluate the severity of sepsis. |
format | Online Article Text |
id | pubmed-9976484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99764842023-03-02 Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates Guo, Junfei Lai, Weiming Wu, Yongbing Li, Huan Fu, Zhenhua Mu, Xiaoping Eur J Med Res Research BACKGROUND: Changes of serum lipoprotein concentration during bacteremia or sepsis are observed and lipoproteins concentration facilitate the evaluation severity of sepsis in adults, but its clinical usage is still unclear. Here, we analyzed the lipoprotein concentration in neonates with sepsis and discussed its use in stratifying patients. METHODS: This is a retrospective study involved 88 culture-proven septic patients. Clinical and microbiology data of involved patients were collected via inquiring databases of our institute. Patients were grouped according to blood culture results or procalcitonin level; the difference between groups were analyzed. RESULTS: Compared with uninfected group, there is no change of triglyceride (TG) concentrations and significant decrease of Total cholesterol (TC) concentration in septic patients. There is no significant difference between Gram-positive and Gram-negative-related septic patients in terms of serum TG and TC concentration. Other than group with procalcitonin level of 0.5–2 ng/ml, both serum TG and TC concentration were decreased while serum procalcitonin level increasing. CONCLUSIONS: Our results indicated that serum lipoprotein concentration may be recommended to help diagnosis of bacteria and to evaluate the severity of sepsis. BioMed Central 2023-03-01 /pmc/articles/PMC9976484/ /pubmed/36855137 http://dx.doi.org/10.1186/s40001-023-01077-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Guo, Junfei Lai, Weiming Wu, Yongbing Li, Huan Fu, Zhenhua Mu, Xiaoping Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title | Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title_full | Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title_fullStr | Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title_full_unstemmed | Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title_short | Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
title_sort | change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976484/ https://www.ncbi.nlm.nih.gov/pubmed/36855137 http://dx.doi.org/10.1186/s40001-023-01077-8 |
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