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Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis

OBJECTIVE: The purpose of this study was to provide evidence for early life care by meta-analyzing the relationship between infection during pregnancy and up to 2 years of age and the risk of subsequent allergic rhinitis (AR). METHODS: Published studies up to April 2022 were systematically searched...

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Autores principales: Chen, JunRong, Liu, Xiaohua, Liu, Zixin, Zhou, Yaqian, Xie, Li, Zhang, Jialin, Tan, Jin, Yang, Yide, Tian, Mei, Dong, Yunpeng, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976500/
https://www.ncbi.nlm.nih.gov/pubmed/36859178
http://dx.doi.org/10.1186/s12887-023-03870-0
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author Chen, JunRong
Liu, Xiaohua
Liu, Zixin
Zhou, Yaqian
Xie, Li
Zhang, Jialin
Tan, Jin
Yang, Yide
Tian, Mei
Dong, Yunpeng
Li, Jian
author_facet Chen, JunRong
Liu, Xiaohua
Liu, Zixin
Zhou, Yaqian
Xie, Li
Zhang, Jialin
Tan, Jin
Yang, Yide
Tian, Mei
Dong, Yunpeng
Li, Jian
author_sort Chen, JunRong
collection PubMed
description OBJECTIVE: The purpose of this study was to provide evidence for early life care by meta-analyzing the relationship between infection during pregnancy and up to 2 years of age and the risk of subsequent allergic rhinitis (AR). METHODS: Published studies up to April 2022 were systematically searched in PubMed, Embase, Web of Science, Cochrane Library, SinoMed, CNKI, Wanfang Database, and VIP. Literature screening, including quality assessment, was performed, and the effect values (OR, HR, RR) and 95% confidence intervals (95% CI) of infection during pregnancy and up to 2 years of age and allergic rhinitis were extracted from each qualified study. RESULTS: In total, 5 studies with a sample size of 82,256 reported the relationship between infection during pregnancy and offspring AR. Meta-analysis showed that maternal infection during pregnancy was associated with an increased risk of childhood AR in offspring (OR = 1.34, 95% CI: 1.08–1.67). Altogether, 13 studies with a sample size of 78,426 reported evidence of an association between infection within 2 years of age and subsequent AR in children. A pooled meta-analysis of all studies showed that early infection within 2 years of age was closely associated with childhood AR (OR = 1.25, 95% CI: 1.12–1.40), especially upper respiratory tract infection (OR = 1.32, 95% CI: 1.06–1.65) and gastrointestinal infections (OR = 1.37, 95% CI: 1.01–1.86), but ear infection showed similar results in the cohort study (OR = 1.13, 95% CI: 1.04–1.22). CONCLUSION: Current evidence suggests that infection during pregnancy, early upper respiratory infection, gastrointestinal infections and ear infection within 2 years of age would increase the risk of AR in children. Therefore, the prevention of infection during pregnancy and in infancy and young children needs to be emphasized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03870-0.
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spelling pubmed-99765002023-03-02 Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis Chen, JunRong Liu, Xiaohua Liu, Zixin Zhou, Yaqian Xie, Li Zhang, Jialin Tan, Jin Yang, Yide Tian, Mei Dong, Yunpeng Li, Jian BMC Pediatr Research OBJECTIVE: The purpose of this study was to provide evidence for early life care by meta-analyzing the relationship between infection during pregnancy and up to 2 years of age and the risk of subsequent allergic rhinitis (AR). METHODS: Published studies up to April 2022 were systematically searched in PubMed, Embase, Web of Science, Cochrane Library, SinoMed, CNKI, Wanfang Database, and VIP. Literature screening, including quality assessment, was performed, and the effect values (OR, HR, RR) and 95% confidence intervals (95% CI) of infection during pregnancy and up to 2 years of age and allergic rhinitis were extracted from each qualified study. RESULTS: In total, 5 studies with a sample size of 82,256 reported the relationship between infection during pregnancy and offspring AR. Meta-analysis showed that maternal infection during pregnancy was associated with an increased risk of childhood AR in offspring (OR = 1.34, 95% CI: 1.08–1.67). Altogether, 13 studies with a sample size of 78,426 reported evidence of an association between infection within 2 years of age and subsequent AR in children. A pooled meta-analysis of all studies showed that early infection within 2 years of age was closely associated with childhood AR (OR = 1.25, 95% CI: 1.12–1.40), especially upper respiratory tract infection (OR = 1.32, 95% CI: 1.06–1.65) and gastrointestinal infections (OR = 1.37, 95% CI: 1.01–1.86), but ear infection showed similar results in the cohort study (OR = 1.13, 95% CI: 1.04–1.22). CONCLUSION: Current evidence suggests that infection during pregnancy, early upper respiratory infection, gastrointestinal infections and ear infection within 2 years of age would increase the risk of AR in children. Therefore, the prevention of infection during pregnancy and in infancy and young children needs to be emphasized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03870-0. BioMed Central 2023-03-01 /pmc/articles/PMC9976500/ /pubmed/36859178 http://dx.doi.org/10.1186/s12887-023-03870-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, JunRong
Liu, Xiaohua
Liu, Zixin
Zhou, Yaqian
Xie, Li
Zhang, Jialin
Tan, Jin
Yang, Yide
Tian, Mei
Dong, Yunpeng
Li, Jian
Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title_full Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title_fullStr Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title_full_unstemmed Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title_short Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
title_sort early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976500/
https://www.ncbi.nlm.nih.gov/pubmed/36859178
http://dx.doi.org/10.1186/s12887-023-03870-0
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