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Evolution-inspired engineering of anthracycline methyltransferases

Streptomyces soil bacteria produce hundreds of anthracycline anticancer agents with a relatively conserved set of genes. This diversity depends on the rapid evolution of biosynthetic enzymes to acquire novel functionalities. Previous work has identified S-adenosyl-l-methionine-dependent methyltransf...

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Detalles Bibliográficos
Autores principales:	Dinis, Pedro, Tirkkonen, Heli, Wandi, Benjamin Nji, Siitonen, Vilja, Niemi, Jarmo, Grocholski, Thadée, Metsä-Ketelä, Mikko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976750/ https://www.ncbi.nlm.nih.gov/pubmed/36874276 http://dx.doi.org/10.1093/pnasnexus/pgad009

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