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Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer
OBJECTIVES: The aim of this study was to compare short-term outcomes and local control in pT1c pN0 non-small-cell lung cancer that were intentionally treated by video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy. METHODS: Multicentre retrospective study of consecutive patients un...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976754/ https://www.ncbi.nlm.nih.gov/pubmed/36856745 http://dx.doi.org/10.1093/icvts/ivad037 |
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author | Forster, Céline Abdelnour-Berchtold, Etienne Bédat, Benoît Perentes, Jean Yannis Zellweger, Matthieu Sauvain, Marc-Olivier Christodoulou, Michel Triponez, Frédéric Karenovics, Wolfram Krueger, Thorsten Gonzalez, Michel |
author_facet | Forster, Céline Abdelnour-Berchtold, Etienne Bédat, Benoît Perentes, Jean Yannis Zellweger, Matthieu Sauvain, Marc-Olivier Christodoulou, Michel Triponez, Frédéric Karenovics, Wolfram Krueger, Thorsten Gonzalez, Michel |
author_sort | Forster, Céline |
collection | PubMed |
description | OBJECTIVES: The aim of this study was to compare short-term outcomes and local control in pT1c pN0 non-small-cell lung cancer that were intentionally treated by video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy. METHODS: Multicentre retrospective study of consecutive patients undergoing VATS lobectomy (VL) or VATS segmentectomy (VS) for pT1c pN0 non-small-cell lung cancer from January 2014 to October 2021. Patients’ characteristics, postoperative outcomes and survival were compared. RESULTS: In total, 162 patients underwent VL (n = 81) or VS (n = 81). Except for age [median (interquartile range) 68 (60–73) vs 71 (65–76) years; P = 0.034] and past medical history of cancer (32% vs 48%; P = 0.038), there was no difference between VL and VS in terms of demographics and comorbidities. Overall 30-day postoperative morbidity was similar in both groups (34% vs 30%; P = 0.5). The median time for chest tube removal [3 (1–5) vs 2 (1–3) days; P = 0.002] and median postoperative length of stay [6 (4–9) vs 5 (3–7) days; P = 0.039] were in favour of the VS group. Significantly larger tumour size (mean ± standard deviation 25.1 ± 3.1 vs 23.6 ± 3.1 mm; P = 0.001) and an increased number of lymph nodes removal [median (interquartile range) 14 (9–23) vs 10 (6–15); P < 0.001] were found in the VL group. During the follow-up [median (interquartile range) 31 (14–48) months], no statistical difference was found for local and distant recurrence in VL groups (12.3%) and VS group (6.1%) (P = 0.183). Overall survival (80% vs 80%) was comparable between both groups (P = 0.166). CONCLUSIONS: Despite a short follow-up, our preliminary data shows that local control is comparable for VL and VS. |
format | Online Article Text |
id | pubmed-9976754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99767542023-03-02 Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer Forster, Céline Abdelnour-Berchtold, Etienne Bédat, Benoît Perentes, Jean Yannis Zellweger, Matthieu Sauvain, Marc-Olivier Christodoulou, Michel Triponez, Frédéric Karenovics, Wolfram Krueger, Thorsten Gonzalez, Michel Interdiscip Cardiovasc Thorac Surg Thoracic Oncology OBJECTIVES: The aim of this study was to compare short-term outcomes and local control in pT1c pN0 non-small-cell lung cancer that were intentionally treated by video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy. METHODS: Multicentre retrospective study of consecutive patients undergoing VATS lobectomy (VL) or VATS segmentectomy (VS) for pT1c pN0 non-small-cell lung cancer from January 2014 to October 2021. Patients’ characteristics, postoperative outcomes and survival were compared. RESULTS: In total, 162 patients underwent VL (n = 81) or VS (n = 81). Except for age [median (interquartile range) 68 (60–73) vs 71 (65–76) years; P = 0.034] and past medical history of cancer (32% vs 48%; P = 0.038), there was no difference between VL and VS in terms of demographics and comorbidities. Overall 30-day postoperative morbidity was similar in both groups (34% vs 30%; P = 0.5). The median time for chest tube removal [3 (1–5) vs 2 (1–3) days; P = 0.002] and median postoperative length of stay [6 (4–9) vs 5 (3–7) days; P = 0.039] were in favour of the VS group. Significantly larger tumour size (mean ± standard deviation 25.1 ± 3.1 vs 23.6 ± 3.1 mm; P = 0.001) and an increased number of lymph nodes removal [median (interquartile range) 14 (9–23) vs 10 (6–15); P < 0.001] were found in the VL group. During the follow-up [median (interquartile range) 31 (14–48) months], no statistical difference was found for local and distant recurrence in VL groups (12.3%) and VS group (6.1%) (P = 0.183). Overall survival (80% vs 80%) was comparable between both groups (P = 0.166). CONCLUSIONS: Despite a short follow-up, our preliminary data shows that local control is comparable for VL and VS. Oxford University Press 2023-02-14 /pmc/articles/PMC9976754/ /pubmed/36856745 http://dx.doi.org/10.1093/icvts/ivad037 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Thoracic Oncology Forster, Céline Abdelnour-Berchtold, Etienne Bédat, Benoît Perentes, Jean Yannis Zellweger, Matthieu Sauvain, Marc-Olivier Christodoulou, Michel Triponez, Frédéric Karenovics, Wolfram Krueger, Thorsten Gonzalez, Michel Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title | Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title_full | Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title_fullStr | Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title_full_unstemmed | Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title_short | Local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pT1c pN0 non-small-cell lung cancer |
title_sort | local control and short-term outcomes after video-assisted thoracoscopic surgery segmentectomy versus lobectomy for pt1c pn0 non-small-cell lung cancer |
topic | Thoracic Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976754/ https://www.ncbi.nlm.nih.gov/pubmed/36856745 http://dx.doi.org/10.1093/icvts/ivad037 |
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