Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes

BACKGROUND: Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but their importance is unclear because of the multifactorial background of renal fibrosis. This study explores the pro-fibrotic respo...

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Detalles Bibliográficos
Autores principales: Knops, Noël, Ramazani, Yasaman, De Loor, Henriëtte, Goldschmeding, Roel, Nguyen, Tri Q, van den Heuvel, Lambert P, Levtchenko, Elena, Kuypers, Dirk J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976759/
https://www.ncbi.nlm.nih.gov/pubmed/35945682
http://dx.doi.org/10.1093/ndt/gfac237

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