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The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

DNA double-strand breaks (DSBs) can be repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). NHEJ is induced by the binding to DSBs of the Ku70–Ku80 heterodimer, which acts as a hub for the recruitment of downstream NHEJ components. An important issue in DSB repair i...

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Detalles Bibliográficos
Autores principales:	Rinaldi, Carlo, Pizzul, Paolo, Casari, Erika, Mangiagalli, Marco, Tisi, Renata, Longhese, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976877/ https://www.ncbi.nlm.nih.gov/pubmed/36762474 http://dx.doi.org/10.1093/nar/gkad062

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