Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein

RNA binding proteins (RBPs) often engage multiple RNA binding domains (RBDs) to increase target specificity and affinity. However, the complexity of target recognition of multiple RBDs remains largely unexplored. Here we use Upstream of N-Ras (Unr), a multidomain RBP, to demonstrate how multiple RBD...

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Detalles Bibliográficos
Autores principales: Hollmann, Nele Merret, Jagtap, Pravin Kumar Ankush, Linse, Johanna-Barbara, Ullmann, Philip, Payr, Marco, Murciano, Brice, Simon, Bernd, Hub, Jochen S, Hennig, Janosch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976900/
https://www.ncbi.nlm.nih.gov/pubmed/36688322
http://dx.doi.org/10.1093/nar/gkac1277

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