Cargando…

Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing

DNA strand breaks are repaired by DNA synthesis from an exposed DNA end paired with a homologous DNA template. DNA polymerase delta (Pol δ) catalyses DNA synthesis in multiple eukaryotic DNA break repair pathways but triggers genome instability unless its activity is restrained. We show that human H...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Liu, Lever, Rebecca, Cubbon, Andrew, Tehseen, Muhammad, Jenkins, Tabitha, Nottingham, Alice O, Horton, Anya, Betts, Hannah, Fisher, Martin, Hamdan, Samir M, Soultanas, Panos, Bolt, Edward L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976902/ https://www.ncbi.nlm.nih.gov/pubmed/36718939 http://dx.doi.org/10.1093/nar/gkad032

Ejemplares similares

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
por: Jenkins, Tabitha, et al.
Publicado: (2021)

Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing
por: Lever, Rebecca J, et al.
Publicado: (2023)

Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis
por: Rannou, Olivier, et al.
Publicado: (2013)

Helq acts in parallel to Fancc to suppress replication-associated genome instability
por: Luebben, Spencer W., et al.
Publicado: (2013)

SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation
por: Winterhalter, Charles, et al.
Publicado: (2022)

Intracellular dynamics of archaeal FANCM homologue Hef in response to halted DNA replication
por: Lestini, Roxane, et al.
Publicado: (2013)

DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis
por: Grainger, William H., et al.
Publicado: (2010)

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites
por: Collier, Christopher, et al.
Publicado: (2012)

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing
por: Kanter, Diane M., et al.
Publicado: (2011)

The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin
por: Winterhalter, Charles, et al.
Publicado: (2023)

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD
por: Marston, Farhat Y., et al.
Publicado: (2010)

RecO-mediated DNA homology search and annealing is facilitated by SsbA
por: Manfredi, Candela, et al.
Publicado: (2010)

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes
por: Grimme, Jill M., et al.
Publicado: (2010)

Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex
por: You, Zhiying, et al.
Publicado: (2017)

The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
por: Keller, Heidi, et al.
Publicado: (2014)

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
por: Paliwal, Shreya, et al.
Publicado: (2014)

Interaction of Rep and DnaB on DNA
por: Atkinson, John, et al.
Publicado: (2011)

Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7
por: Lee, Seung-Joo, et al.
Publicado: (2010)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA
por: Furukohri, Asako, et al.
Publicado: (2012)

DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA
por: Mórocz, Mónika, et al.
Publicado: (2017)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
por: Obi, Ikenna, et al.
Publicado: (2020)

Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis
por: Zhai, Binyuan, et al.
Publicado: (2023)

Metal-induced DNA translocation leads to DNA polymerase conformational activation
por: Kirby, Thomas W., et al.
Publicado: (2012)

Inhibition of DNA damage repair by artificial activation of PARP with siDNA
por: Croset, Amelie, et al.
Publicado: (2013)

Dna2 initiates resection at clean DNA double-strand breaks
por: Paudyal, Sharad C., et al.
Publicado: (2017)

Quantifying the stability of oxidatively damaged DNA by single-molecule DNA stretching
por: McCauley, Micah J, et al.
Publicado: (2018)

RAD51 interconnects between DNA replication, DNA repair and immunity
por: Bhattacharya, Souparno, et al.
Publicado: (2017)

Ultraviolet-induced RNA:DNA hybrids interfere with chromosomal DNA synthesis
por: Kouzminova, Elena A, et al.
Publicado: (2021)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Evolutionary patterns of DNA base composition and correlation to polymorphisms in DNA repair systems
por: Li, Xianran, et al.
Publicado: (2015)

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
por: Sen, Doyel, et al.
Publicado: (2016)

Stress-inducible NHEJ in bacteria: function in DNA repair and acquisition of heterologous DNA
por: Dupuy, Pierre, et al.
Publicado: (2019)

Catalytically inactive DNA ligase IV promotes DNA repair in living cells
por: Goff, Noah J, et al.
Publicado: (2022)

C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair
por: McGovern, Stephen, et al.
Publicado: (2016)

Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9
por: Yoo, Kyung W, et al.
Publicado: (2022)

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA
por: Gueranger, Quentin, et al.
Publicado: (2011)

Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase
por: Mohan, Ryan D., et al.
Publicado: (2010)

Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
por: Sarangi, Prabha, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ilhj8ele29c2ai29nmirtehtkj