eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how these mRNAs recruit and activate eIF4A1 unwinding specifically to facilitate their preferential translation. Here, we show that sin...

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Detalles Bibliográficos
Autores principales: Schmidt, Tobias, Dabrowska, Adrianna, Waldron, Joseph A, Hodge, Kelly, Koulouras, Grigorios, Gabrielsen, Mads, Munro, June, Tack, David C, Harris, Gemma, McGhee, Ewan, Scott, David, Carlin, Leo M, Huang, Danny, Le Quesne, John, Zanivan, Sara, Wilczynska, Ania, Bushell, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976904/
https://www.ncbi.nlm.nih.gov/pubmed/36727461
http://dx.doi.org/10.1093/nar/gkad030

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