P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

Positive transcription elongation factor b (P-TEFb) is the crucial player in RNA polymerase II (Pol II) pause release that has emerged as a promising target in cancer. Because single-agent therapy may fail to deliver durable clinical response, targeting of P-TEFb shall benefit when deployed as a com...

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Detalles Bibliográficos
Autores principales: Wang, Zhijia, Mačáková, Monika, Bugai, Andrii, Kuznetsov, Sergey G, Hassinen, Antti, Lenasi, Tina, Potdar, Swapnil, Friedel, Caroline C, Barborič, Matjaž
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976905/
https://www.ncbi.nlm.nih.gov/pubmed/36727434
http://dx.doi.org/10.1093/nar/gkad001

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