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Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures

Promoter-proximal Polymerase II (Pol II) pausing is a key rate-limiting step for gene expression. DNA and RNA-binding trans-acting factors regulating the extent of pausing have been identified. However, we lack a quantitative model of how interactions of these factors determine pausing, therefore th...

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Detalles Bibliográficos
Autores principales:	Akcan, Toray S, Vilov, Sergey, Heinig, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976927/ https://www.ncbi.nlm.nih.gov/pubmed/36727445 http://dx.doi.org/10.1093/nar/gkac1272

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