Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ct...

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Detalles Bibliográficos
Autores principales: De Sarkar, Navonil, Patton, Robert D., Doebley, Anna-Lisa, Hanratty, Brian, Adil, Mohamed, Kreitzman, Adam J., Sarthy, Jay F., Ko, Minjeong, Brahma, Sandipan, Meers, Michael P., Janssens, Derek H., Ang, Lisa S., Coleman, Ilsa M., Bose, Arnab, Dumpit, Ruth F., Lucas, Jared M., Nunez, Talina A., Nguyen, Holly M., McClure, Heather M., Pritchard, Colin C., Schweizer, Michael T., Morrissey, Colm, Choudhury, Atish D., Baca, Sylvan C., Berchuck, Jacob E., Freedman, Matthew L., Ahmad, Kami, Haffner, Michael C., Montgomery, R. Bruce, Corey, Eva, Henikoff, Steven, Nelson, Peter S., Ha, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976992/
https://www.ncbi.nlm.nih.gov/pubmed/36399432
http://dx.doi.org/10.1158/2159-8290.CD-22-0692

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