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Causes of death of patients with non-valvular atrial fibrillation in Asians
OBJECTIVES: The aim of this study was to determine the causes of death among Asian non-valvular atrial fibrillation (AF) patients who were registered in a nationwide AF registry, and to investigate the differences in the causes of death in AF patients compared between those who were taking and not t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977019/ https://www.ncbi.nlm.nih.gov/pubmed/36857361 http://dx.doi.org/10.1371/journal.pone.0282455 |
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author | Krittayaphong, Rungroj Boonyapiphat, Thanita Aroonsiriwattana, Suchart Ngamjanyaporn, Pornchai Lip, Gregory Y. H. |
author_facet | Krittayaphong, Rungroj Boonyapiphat, Thanita Aroonsiriwattana, Suchart Ngamjanyaporn, Pornchai Lip, Gregory Y. H. |
author_sort | Krittayaphong, Rungroj |
collection | PubMed |
description | OBJECTIVES: The aim of this study was to determine the causes of death among Asian non-valvular atrial fibrillation (AF) patients who were registered in a nationwide AF registry, and to investigate the differences in the causes of death in AF patients compared between those who were taking and not taking oral anticoagulant (OAC). METHODS: The COhort of antithrombotic use and Optimal INR Level in patients with non-valvular Atrial Fibrillation in Thailand (COOL-AF) study enrolled non-valvular AF patients from 27 centers in Thailand during 2014–2017 to create the COOL-AF Thailand registry. Cause of death was classified as cardiovascular (CV) death, non-CV death, or undetermined cause of death. All events were evaluated and verified by an independent adjudication committee. RESULTS: There was a total of 3,405 patients (mean age: 67.8 years, 41.8% female), and the mean follow-up duration was 31.8±8.7 months. Three hundred and eighty patients (11.2%) died during follow-up. CV death, non-CV death, and undetermined cause accounted for 121 (31.8%), 189 (49.7%), and 70 (18.4%) patients, respectively. Of those with a known cause of death, heart failure (10%), intracranial hemorrhage (ICH; 10%), sudden cardiac death (6.8%), and ischemic stroke (5.8%) were the most often observed causes of death. Concerning non-CV death, infection/sepsis (27.7%), cancer (5.5%), respiratory (5.2%), and major bleeding (4.5%) were the most prevalent causes of death. The use and type of OAC were found to be major determinants of ICH and major bleeding incidence. CONCLUSION: Death due to ischemic stroke was responsible for only 4.7% of all deaths in Asian AF patients. Non-CV death, such as infection/sepsis or malignancy, was more far more prevalent than CV death in Asian AF patients. An improved integrated care approach is needed to reduce the prevalence of non-CV death in Asian AF patients. |
format | Online Article Text |
id | pubmed-9977019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99770192023-03-02 Causes of death of patients with non-valvular atrial fibrillation in Asians Krittayaphong, Rungroj Boonyapiphat, Thanita Aroonsiriwattana, Suchart Ngamjanyaporn, Pornchai Lip, Gregory Y. H. PLoS One Research Article OBJECTIVES: The aim of this study was to determine the causes of death among Asian non-valvular atrial fibrillation (AF) patients who were registered in a nationwide AF registry, and to investigate the differences in the causes of death in AF patients compared between those who were taking and not taking oral anticoagulant (OAC). METHODS: The COhort of antithrombotic use and Optimal INR Level in patients with non-valvular Atrial Fibrillation in Thailand (COOL-AF) study enrolled non-valvular AF patients from 27 centers in Thailand during 2014–2017 to create the COOL-AF Thailand registry. Cause of death was classified as cardiovascular (CV) death, non-CV death, or undetermined cause of death. All events were evaluated and verified by an independent adjudication committee. RESULTS: There was a total of 3,405 patients (mean age: 67.8 years, 41.8% female), and the mean follow-up duration was 31.8±8.7 months. Three hundred and eighty patients (11.2%) died during follow-up. CV death, non-CV death, and undetermined cause accounted for 121 (31.8%), 189 (49.7%), and 70 (18.4%) patients, respectively. Of those with a known cause of death, heart failure (10%), intracranial hemorrhage (ICH; 10%), sudden cardiac death (6.8%), and ischemic stroke (5.8%) were the most often observed causes of death. Concerning non-CV death, infection/sepsis (27.7%), cancer (5.5%), respiratory (5.2%), and major bleeding (4.5%) were the most prevalent causes of death. The use and type of OAC were found to be major determinants of ICH and major bleeding incidence. CONCLUSION: Death due to ischemic stroke was responsible for only 4.7% of all deaths in Asian AF patients. Non-CV death, such as infection/sepsis or malignancy, was more far more prevalent than CV death in Asian AF patients. An improved integrated care approach is needed to reduce the prevalence of non-CV death in Asian AF patients. Public Library of Science 2023-03-01 /pmc/articles/PMC9977019/ /pubmed/36857361 http://dx.doi.org/10.1371/journal.pone.0282455 Text en © 2023 Krittayaphong et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Krittayaphong, Rungroj Boonyapiphat, Thanita Aroonsiriwattana, Suchart Ngamjanyaporn, Pornchai Lip, Gregory Y. H. Causes of death of patients with non-valvular atrial fibrillation in Asians |
title | Causes of death of patients with non-valvular atrial fibrillation in Asians |
title_full | Causes of death of patients with non-valvular atrial fibrillation in Asians |
title_fullStr | Causes of death of patients with non-valvular atrial fibrillation in Asians |
title_full_unstemmed | Causes of death of patients with non-valvular atrial fibrillation in Asians |
title_short | Causes of death of patients with non-valvular atrial fibrillation in Asians |
title_sort | causes of death of patients with non-valvular atrial fibrillation in asians |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977019/ https://www.ncbi.nlm.nih.gov/pubmed/36857361 http://dx.doi.org/10.1371/journal.pone.0282455 |
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