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Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization

OBJECTIVES: To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence. METHODS: We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psor...

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Autores principales: Zhao, Sizheng Steven, Bellou, Eftychia, Verstappen, Suzanne M M, Cook, Michael J, Sergeant, Jamie C, Warren, Richard B, Barton, Anne, Bowes, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977114/
https://www.ncbi.nlm.nih.gov/pubmed/35861400
http://dx.doi.org/10.1093/rheumatology/keac403
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author Zhao, Sizheng Steven
Bellou, Eftychia
Verstappen, Suzanne M M
Cook, Michael J
Sergeant, Jamie C
Warren, Richard B
Barton, Anne
Bowes, John
author_facet Zhao, Sizheng Steven
Bellou, Eftychia
Verstappen, Suzanne M M
Cook, Michael J
Sergeant, Jamie C
Warren, Richard B
Barton, Anne
Bowes, John
author_sort Zhao, Sizheng Steven
collection PubMed
description OBJECTIVES: To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence. METHODS: We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psoriatic disease and lifestyle factors (including BMI and smoking) and 15 comorbidities [including diabetes and coronary artery disease (CAD)] using logistic models adjusted for age, sex and lifestyle factors. We applied bidirectional Mendelian randomization (MR) to genome-wide association data (3609 PsA and 7804 psoriasis cases, up to 1.2 million individuals for lifestyle factors and 757 601 for comorbidities) to examine causal direction, using the inverse-variance weighted method. RESULTS: BMI was cross-sectionally associated with risk of PsA (OR 1.31 per 5 kg/m(2) increase; 95% CI 1.26, 1.37) and psoriasis (OR 1.23; 1.20, 1.26), with consistent MR estimates (PsA OR 1.38; 1.14, 1.67; psoriasis OR 1.36; 1.18, 1.58). In both designs, smoking was more strongly associated with psoriasis than PsA. PsA and psoriasis were cross-sectionally associated with diabetes (OR 1.35 and 1.39, respectively) and CAD (OR 1.56 and 1.38, respective). Genetically predicted glycated haemoglobin (surrogate for diabetes) increased PsA risk (OR 1.18 per 6.7 mmol/mol increase; 1.02, 1.36) but not psoriasis. Genetic liability to PsA (OR 1.05; 1.003, 1.09) and psoriasis (OR 1.03; 1.001, 1.06) were associated with increased risk of CAD. CONCLUSION: Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk. Further research is needed to understand the mechanism of these associations.
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spelling pubmed-99771142023-03-02 Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization Zhao, Sizheng Steven Bellou, Eftychia Verstappen, Suzanne M M Cook, Michael J Sergeant, Jamie C Warren, Richard B Barton, Anne Bowes, John Rheumatology (Oxford) Basic Science OBJECTIVES: To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence. METHODS: We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psoriatic disease and lifestyle factors (including BMI and smoking) and 15 comorbidities [including diabetes and coronary artery disease (CAD)] using logistic models adjusted for age, sex and lifestyle factors. We applied bidirectional Mendelian randomization (MR) to genome-wide association data (3609 PsA and 7804 psoriasis cases, up to 1.2 million individuals for lifestyle factors and 757 601 for comorbidities) to examine causal direction, using the inverse-variance weighted method. RESULTS: BMI was cross-sectionally associated with risk of PsA (OR 1.31 per 5 kg/m(2) increase; 95% CI 1.26, 1.37) and psoriasis (OR 1.23; 1.20, 1.26), with consistent MR estimates (PsA OR 1.38; 1.14, 1.67; psoriasis OR 1.36; 1.18, 1.58). In both designs, smoking was more strongly associated with psoriasis than PsA. PsA and psoriasis were cross-sectionally associated with diabetes (OR 1.35 and 1.39, respectively) and CAD (OR 1.56 and 1.38, respective). Genetically predicted glycated haemoglobin (surrogate for diabetes) increased PsA risk (OR 1.18 per 6.7 mmol/mol increase; 1.02, 1.36) but not psoriasis. Genetic liability to PsA (OR 1.05; 1.003, 1.09) and psoriasis (OR 1.03; 1.001, 1.06) were associated with increased risk of CAD. CONCLUSION: Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk. Further research is needed to understand the mechanism of these associations. Oxford University Press 2022-07-21 /pmc/articles/PMC9977114/ /pubmed/35861400 http://dx.doi.org/10.1093/rheumatology/keac403 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Basic Science
Zhao, Sizheng Steven
Bellou, Eftychia
Verstappen, Suzanne M M
Cook, Michael J
Sergeant, Jamie C
Warren, Richard B
Barton, Anne
Bowes, John
Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title_full Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title_fullStr Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title_full_unstemmed Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title_short Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
title_sort association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and mendelian randomization
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977114/
https://www.ncbi.nlm.nih.gov/pubmed/35861400
http://dx.doi.org/10.1093/rheumatology/keac403
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