A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy

Tropical pulmonary eosinophilia (TPE) is a specific pulmonary manifestation of lymphatic filariasis. There is overwhelming infiltration of eosinophils in the lung parenchyma in response to microfilaria. The characteristic features include paroxysmal respiratory symptoms, strikingly high blood eosino...

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Autores principales: Datta, Ananda, Chhotray, Pritam, Jena, Banani, Sivasankar, Raghavendrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Radiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977209/
https://www.ncbi.nlm.nih.gov/pubmed/36874679
http://dx.doi.org/10.7759/cureus.34359
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author Datta, Ananda
Chhotray, Pritam
Jena, Banani
Sivasankar, Raghavendrun
author_facet Datta, Ananda
Chhotray, Pritam
Jena, Banani
Sivasankar, Raghavendrun
author_sort Datta, Ananda
collection PubMed
description Tropical pulmonary eosinophilia (TPE) is a specific pulmonary manifestation of lymphatic filariasis. There is overwhelming infiltration of eosinophils in the lung parenchyma in response to microfilaria. The characteristic features include paroxysmal respiratory symptoms, strikingly high blood eosinophil count, elevated level of immunoglobulin (Ig) E along with high titer of anti-filarial antibody. Treatment with diethylcarbamazine (DEC) has an excellent favorable response. However, recovery may often be incomplete. We present a case of a 36-year-old man with TPE who had complete symptomatic improvement after a three-week course of DEC, but only a partial response in radiological and pulmonary function abnormalities. 
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spelling pubmed-99772092023-03-02 A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy Datta, Ananda Chhotray, Pritam Jena, Banani Sivasankar, Raghavendrun Cureus Radiology Tropical pulmonary eosinophilia (TPE) is a specific pulmonary manifestation of lymphatic filariasis. There is overwhelming infiltration of eosinophils in the lung parenchyma in response to microfilaria. The characteristic features include paroxysmal respiratory symptoms, strikingly high blood eosinophil count, elevated level of immunoglobulin (Ig) E along with high titer of anti-filarial antibody. Treatment with diethylcarbamazine (DEC) has an excellent favorable response. However, recovery may often be incomplete. We present a case of a 36-year-old man with TPE who had complete symptomatic improvement after a three-week course of DEC, but only a partial response in radiological and pulmonary function abnormalities.  Cureus 2023-01-29 /pmc/articles/PMC9977209/ /pubmed/36874679 http://dx.doi.org/10.7759/cureus.34359 Text en Copyright © 2023, Datta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Datta, Ananda
Chhotray, Pritam
Jena, Banani
Sivasankar, Raghavendrun
A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title_full A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title_fullStr A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title_full_unstemmed A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title_short A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy
title_sort case of tropical pulmonary eosinophilia with incomplete response to diethylcarbamazine therapy
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977209/
https://www.ncbi.nlm.nih.gov/pubmed/36874679
http://dx.doi.org/10.7759/cureus.34359
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