Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4(+) T cells

CD4(+) T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor-specific CD4(+) T cells is unclear. We isolated...

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Detalles Bibliográficos
Autores principales: Brightman, Spencer E., Naradikian, Martin S., Thota, Rukman R., Becker, Angelica, Montero, Leslie, Bahmanof, Milad, Premlal, Ashmitaa Logandha Ramamoorthy, Greenbaum, Jason A., Peters, Bjoern, Cohen, Ezra E.W., Miller, Aaron M., Schoenberger, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977289/
https://www.ncbi.nlm.nih.gov/pubmed/36512410
http://dx.doi.org/10.1172/jci.insight.165570

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