Cargando…

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

Medium-chain triglycerides (MCTs), which consist of medium-chain fatty acids (MCFAs), are unique forms of dietary fat with various health benefits. G protein–coupled 84 (GPR84) acts as a receptor for MCFAs (especially C10:0 and C12:0); however, GPR84 is still considered an orphan receptor, and the n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohue-Kitano, Ryuji, Nonaka, Hazuki, Nishida, Akari, Masujima, Yuki, Takahashi, Daisuke, Ikeda, Takako, Uwamizu, Akiharu, Tanaka, Miyako, Kohjima, Motoyuki, Igarashi, Miki, Katoh, Hironori, Tanaka, Tomohiro, Inoue, Asuka, Suganami, Takayoshi, Hase, Koji, Ogawa, Yoshihiro, Aoki, Junken, Kimura, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977302/ https://www.ncbi.nlm.nih.gov/pubmed/36480287 http://dx.doi.org/10.1172/jci.insight.165469

Ejemplares similares

Dietary Medium-Chain Triglyceride Decanoate Affects Glucose Homeostasis Through GPR84-Mediated GLP-1 Secretion in Mice
por: Nonaka, Hazuki, et al.
Publicado: (2022)

Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
por: Tatsumi, Manae, et al.
Publicado: (2023)

3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41
por: Ohue-Kitano, Ryuji, et al.
Publicado: (2023)

Pro-phagocytic function and structural basis of GPR84 signaling
por: Zhang, Xuan, et al.
Publicado: (2023)

GPR84 regulates pulmonary inflammation by modulating neutrophil functions
por: Wang, Si-wei, et al.
Publicado: (2023)

Pro-phagocytic function and structural basis of GPR84 signaling
por: Zhang, Xuan, et al.
Publicado: (2023)

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions
por: Miyamoto, Junki, et al.
Publicado: (2019)

Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice
por: Watanabe, Keita, et al.
Publicado: (2021)

Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84
por: Jenkins, Laura, et al.
Publicado: (2021)

Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists
por: Mahindra, Amit, et al.
Publicado: (2022)

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages
por: Recio, Carlota, et al.
Publicado: (2018)

On-target and off-target effects of novel orthosteric and allosteric activators of GPR84
por: Mancini, Sarah J., et al.
Publicado: (2019)

Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84
por: Marsango, Sara, et al.
Publicado: (2020)

Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
por: Qin, Guohui, et al.
Publicado: (2023)

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
por: Fukasawa, Keiko, et al.
Publicado: (2021)

GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
por: Timmis, Helen, et al.
Publicado: (2021)

DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84
por: Gao, Wen-Shuang, et al.
Publicado: (2020)

Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
por: Marsango, Sara, et al.
Publicado: (2022)

GPR84 potently inhibits osteoclastogenesis and alleviates osteolysis in bone metastasis of colorectal cancer
por: Jian, Li, et al.
Publicado: (2023)

6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84)
por: Pillaiyar, Thanigaimalai, et al.
Publicado: (2018)

Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia
por: Wei, Li, et al.
Publicado: (2017)

Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3
por: Shimizu, Hidenori, et al.
Publicado: (2019)

Molecular mechanism of obesity‐induced ‘metabolic’ tissue remodeling
por: Tanaka, Miyako, et al.
Publicado: (2017)

Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
por: Hachiya, Rumi, et al.
Publicado: (2022)

Expression of the Fatty Acid Receptors GPR84 and GPR120 and Cytodifferentiation of Epithelial Cells in the Gastric Mucosa of Mouse Pups in the Course of Dietary Transition
por: Widmayer, Patricia, et al.
Publicado: (2017)

Molecular Cloning, Tissue Distribution, and Pharmacological Characterization of GPR84 in Grass Carp (Ctenopharyngodon Idella)
por: Li, Yang, et al.
Publicado: (2023)

GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway
por: Lu, Jian, et al.
Publicado: (2022)

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
por: Liu, Heng, et al.
Publicado: (2023)

Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway
por: Shen, Ximei, et al.
Publicado: (2019)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
por: Mahmud, Zobaer Al, et al.
Publicado: (2017)

Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity
por: Amiri Moghaddam, Jamshid, et al.
Publicado: (2018)

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis
por: Puengel, Tobias, et al.
Publicado: (2020)

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
por: Zhang, Qing, et al.
Publicado: (2021)

Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
por: Schulze, Amadeus Samuel, et al.
Publicado: (2022)

Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
por: Mikkelsen, Randi Bonke, et al.
Publicado: (2022)

Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression
por: Müller, Mario M., et al.
Publicado: (2017)

Kcnk3, Ggta1, and Gpr84 are involved in hyperbaric oxygenation preconditioning protection on cerebral ischemia–reperfusion injury
por: Yang, Chunhui, et al.
Publicado: (2021)

Author Correction: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
por: Liu, Heng, et al.
Publicado: (2023)

3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice
por: Ohue-Kitano, Ryuji, et al.
Publicado: (2019)

GPR34 in spinal microglia exacerbates neuropathic pain in mice
por: Sayo, Akira, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uk5to41v46rt7mbv02cua7qtbh