Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01(B) malaria vaccine

Modifications to vaccine delivery that increase serum antibody longevity are of great interest for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing schedule (0-1-6 month) — using AS01(B)-adjuvanted RH5.1 malaria antigen — substantially improves serum IgG durabilit...

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Detalles Bibliográficos
Autores principales: Nielsen, Carolyn M., Barrett, Jordan R., Davis, Christine, Fallon, Jonathan K., Goh, Cyndi, Michell, Ashlin R., Griffin, Catherine, Kwok, Andrew, Loos, Carolin, Darko, Samuel, Laboune, Farida, Tekman, Mehmet, Diouf, Ababacar, Miura, Kazutoyo, Francica, Joseph R., Ransier, Amy, Long, Carole A., Silk, Sarah E., Payne, Ruth O., Minassian, Angela M., Lauffenburger, Douglas A., Seder, Robert A., Douek, Daniel C., Alter, Galit, Draper, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977309/
https://www.ncbi.nlm.nih.gov/pubmed/36692019
http://dx.doi.org/10.1172/jci.insight.163859

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