Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia

Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myelo...

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Detalles Bibliográficos
Autores principales: Stölzel, Friedrich, Fordham, Sarah E., Nandana, Devi, Lin, Wei-Yu, Blair, Helen, Elstob, Claire, Bell, Hayden L., Mohr, Brigitte, Ruhnke, Leo, Kunadt, Desiree, Dill, Claudia, Allsop, Daniel, Piddock, Rachel, Soura, Emmanouela-Niki, Park, Catherine, Fadly, Mohd, Rahman, Thahira, Alharbi, Abrar, Wobus, Manja, Altmann, Heidi, Röllig, Christoph, Wagenführ, Lisa, Jones, Gail L., Menne, Tobias, Jackson, Graham H., Marr, Helen J., Fitzgibbon, Jude, Onel, Kenan, Meggendorfer, Manja, Robinson, Amber, Bziuk, Zuzanna, Bowes, Emily, Heidenreich, Olaf, Haferlach, Torsten, Villar, Sara, Ariceta, Beñat, Diaz, Rosa Ayala, Altschuler, Steven J., Wu, Lani F., Prosper, Felipe, Montesinos, Pau, Martinez-Lopez, Joaquin, Bornhäuser, Martin, Allan, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977313/
https://www.ncbi.nlm.nih.gov/pubmed/36480300
http://dx.doi.org/10.1172/jci.insight.150368

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