Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not TEK receptor tyrosine kinase–positive endothelial...

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Detalles Bibliográficos
Autores principales: Trzaskalski, Natasha A., Vulesevic, Branka, Nguyen, My-Anh, Jeraj, Natasha, Fadzeyeva, Evgenia, Morrow, Nadya M., Locatelli, Cassandra A.A., Travis, Nicole, Hanson, Antonio A., Nunes, Julia R.C., O’Dwyer, Conor, van der Veen, Jelske N., Lorenzen-Schmidt, Ilka, Seymour, Rick, Pulente, Serena M., Clément, Andrew C., Crawley, Angela M., Jacobs, René L., Doyle, Mary-Anne, Cooper, Curtis L., Kim, Kyoung-Han, Fullerton, Morgan D., Mulvihill, Erin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977314/
https://www.ncbi.nlm.nih.gov/pubmed/36472923
http://dx.doi.org/10.1172/jci.insight.154314

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