Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy

The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. IDO expression is also highly induced in human TB granulomas, a...

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Detalles Bibliográficos
Autores principales: Singh, Bindu, Moodley, Chivonne, Singh, Dhiraj K., Escobedo, Ruby A., Sharan, Riti, Arora, Garima, Ganatra, Shashank R., Shivanna, Vinay, Gonzalez, Olga, Hall-Ursone, Shannan, Dick, Edward J., Kaushal, Deepak, Alvarez, Xavier, Mehra, Smriti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977315/
https://www.ncbi.nlm.nih.gov/pubmed/36692017
http://dx.doi.org/10.1172/jci.insight.163101

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