The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

Organic anion transporter 1 (OAT1/SLC22A6, NKT) is a multispecific drug transporter in the kidney with numerous substrates, including pharmaceuticals, endogenous metabolites, natural products, and uremic toxins. Here, we show that OAT1 regulates levels of gut microbiome–derived metabolites. We deple...

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Detalles Bibliográficos
Autores principales: Granados, Jeffry C., Ermakov, Vladimir, Maity, Koustav, Vera, David R., Chang, Geoffrey, Nigam, Sanjay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977316/
https://www.ncbi.nlm.nih.gov/pubmed/36692015
http://dx.doi.org/10.1172/jci.insight.160437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977316/
https://www.ncbi.nlm.nih.gov/pubmed/36692015
http://dx.doi.org/10.1172/jci.insight.160437

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