Cargando…

Mitochondrial and NAD(+) metabolism predict recovery from acute kidney injury in a diverse mouse population

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we used a simple model of folic acid–induced k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morel, Jean-David, Sleiman, Maroun Bou, Li, Terytty Yang, von Alvensleben, Giacomo, Bachmann, Alexis M., Hofer, Dina, Broeckx, Ellen, Ma, Jing Ying, Carreira, Vinicius, Chen, Tao, Azhar, Nabil, Gonzalez-Villalobos, Romer A., Breyer, Matthew, Reilly, Dermot, Mullican, Shannon, Auwerx, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977436/ https://www.ncbi.nlm.nih.gov/pubmed/36752209 http://dx.doi.org/10.1172/jci.insight.164626

Ejemplares similares

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression
por: Benegiamo, Giorgia, et al.
Publicado: (2023)

The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress
por: Li, Terytty Yang, et al.
Publicado: (2021)

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population
por: Li, Xiaoxu, et al.
Publicado: (2023)

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
por: Bou Sleiman, Maroun, et al.
Publicado: (2020)

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains
por: Gao, Arwen W., et al.
Publicado: (2022)

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
por: Matilainen, Olli, et al.
Publicado: (2017)

Exploring the therapeutic space around NAD(+)
por: Houtkooper, Riekelt H., et al.
Publicado: (2012)

Genetic background and sex control the outcome of high-fat diet feeding in mice
por: Bachmann, Alexis Maximilien, et al.
Publicado: (2022)

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis
por: Li, Hao, et al.
Publicado: (2022)

Identifying gene function and module connections by the integration of multispecies expression compendia
por: Li, Hao, et al.
Publicado: (2019)

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution
por: Letizia, Maria Cristina, et al.
Publicado: (2018)

Oncogene-induced NAD(+) depletion in tumorigenesis
por: Tummala, Krishna S., et al.
Publicado: (2015)

Boosting NAD(+) for the prevention and treatment of liver cancer
por: Djouder, Nabil
Publicado: (2015)

Clinical Evidence for Targeting NAD Therapeutically
por: Radenkovic, Dina, et al.
Publicado: (2020)

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs
por: Abele, Florian, et al.
Publicado: (2020)

NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
por: Romani, Mario, et al.
Publicado: (2021)

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence
por: Bou Sleiman, Maroun S., et al.
Publicado: (2015)

Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes
por: Bou Sleiman, Maroun, et al.
Publicado: (2020)

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
por: Li, Terytty Yang, et al.
Publicado: (2023)

Built-in-Self-Test and Digital Self-Calibration for RF SoCs
por: Bou-Sleiman, Sleiman, et al.
Publicado: (2012)

“NAD-capQ” detection and quantitation of NAD caps
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2018)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast Saccharomyces cerevisiae
por: Tsai, Hsieh-Chin, et al.
Publicado: (2022)

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
por: Cerutti, Raffaele, et al.
Publicado: (2014)

NAD to the rescue
por: Tuma, Rabiya S.
Publicado: (2005)

NAD-seq for profiling the NAD(+) capped transcriptome of Arabidopsis thaliana
por: Yu, Xiang, et al.
Publicado: (2021)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

De novo NAD(+) synthesis enhances mitochondrial function and improves health
por: Katsyuba, Elena, et al.
Publicado: (2018)

Enzymatic Properties of Populus α- and β-NAD-ME Recombinant Proteins
por: Liu, Jinwen, et al.
Publicado: (2013)

Das Corona-Virus – Ein Katalysator für Cyberkriminalität?
por: Sleiman, Mohamed Bou
Publicado: (2020)

Development of a Measure of Intergenerational Contact: Implications for Evaluating Intergenerational Programs
por: Turner, Shelbie, et al.
Publicado: (2020)

Identification of NAD-RNA species and ADPR-RNA decapping in Archaea
por: Gomes-Filho, José Vicente, et al.
Publicado: (2023)

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
por: Li, Terytty Yang, et al.
Publicado: (2022)

Quantification of localized NAD(+) changes reveals unique specificity of NAD(+) regulation in the hypothalamus
por: Johnson, Sean, et al.
Publicado: (2023)

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human
por: Benegiamo, Giorgia, et al.
Publicado: (2022)

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria
por: Rodionova, Irina A., et al.
Publicado: (2014)

Evidence that the nadA motif is a bacterial riboswitch for the ubiquitous enzyme cofactor NAD(+)
por: Malkowski, Sarah N., et al.
Publicado: (2019)

Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
por: Sharma, Sunny, et al.
Publicado: (2022)

The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae
por: Odoh, Chuks Kenneth, et al.
Publicado: (2022)

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
por: Buonvicino, Daniela, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mu2tvps32hbo9qso3u4hd2o5fe