Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile

The recent success of antibody–drug conjugates (ADC), exemplified by seven new FDA-approvals within three years, has led to increased attention for antibody based targeted therapeutics and fueled efforts to develop new drug-linker technologies for improved next generation ADCs. We present a highly e...

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Detalles Bibliográficos
Autores principales: Ochtrop, Philipp, Jahzerah, Jahaziel, Machui, Paul, Mai, Isabelle, Schumacher, Dominik, Helma, Jonas, Kasper, Marc-André, Hackenberger, Christian P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977445/
https://www.ncbi.nlm.nih.gov/pubmed/36873847
http://dx.doi.org/10.1039/d2sc05678j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977445/
https://www.ncbi.nlm.nih.gov/pubmed/36873847
http://dx.doi.org/10.1039/d2sc05678j

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