Cargando…
Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile
The recent success of antibody–drug conjugates (ADC), exemplified by seven new FDA-approvals within three years, has led to increased attention for antibody based targeted therapeutics and fueled efforts to develop new drug-linker technologies for improved next generation ADCs. We present a highly e...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977445/ https://www.ncbi.nlm.nih.gov/pubmed/36873847 http://dx.doi.org/10.1039/d2sc05678j |