Model of collective detachment in high-grade serous ovarian cancer demonstrates that tumor spheroids produce ECM to support metastatic processes

High-grade serous ovarian cancer (HGSOC) metastasizes through transcoelomic spread, with both single cells and spheroids of tumor cells observed in patient ascites. These spheroids may form through single cells that detach and aggregate (Sph-SC) or through collective detachment (Sph-CD). We develope...

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Detalles Bibliográficos
Autores principales: Micek, Hannah M., Rosenstock, Lauren, Ma, Yicheng, Hielsberg, Caitlin, Montemorano, Lauren, Gari, Metti K., Ponik, Suzanne M., Kreeger, Pamela K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977464/
https://www.ncbi.nlm.nih.gov/pubmed/36875739
http://dx.doi.org/10.1063/5.0132254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977464/
https://www.ncbi.nlm.nih.gov/pubmed/36875739
http://dx.doi.org/10.1063/5.0132254

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