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A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)

Coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) is responsible for a high mortality rate due to its unique and severe host-pathogen interactions. Critically ill or immunocompromised COVID-19 patients are more prone to suffer from aggressive mycoses. Probable victims include those w...

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Autores principales: Osman, Nermin A., Anwar, Mohammed Moustapha, Singh, Bivek, Gupta, Girish K., Rabie, Amgad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977480/
https://www.ncbi.nlm.nih.gov/pubmed/36859556
http://dx.doi.org/10.1186/s42506-022-00125-1
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author Osman, Nermin A.
Anwar, Mohammed Moustapha
Singh, Bivek
Gupta, Girish K.
Rabie, Amgad M.
author_facet Osman, Nermin A.
Anwar, Mohammed Moustapha
Singh, Bivek
Gupta, Girish K.
Rabie, Amgad M.
author_sort Osman, Nermin A.
collection PubMed
description Coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) is responsible for a high mortality rate due to its unique and severe host-pathogen interactions. Critically ill or immunocompromised COVID-19 patients are more prone to suffer from aggressive mycoses. Probable victims include those with uncontrolled diabetes mellitus (DM), metabolic acidosis, prolonged neutropenia, increased ferritin levels, hypoxia, and prolonged hospitalization with/without mechanical ventilators and corticosteroids administration. The current review aims to outline the journey of patients with CAM as well as the advantages and disadvantages of the currently available diagnostic techniques. It also discussed the current status of treatment options and caveats in the management of mucormycosis. Multidisciplinary team, early diagnosis, controlling the predisposing condition(s), complete surgical debridement, effective antifungal therapies (e.g., amphotericin B, isavuconazole, and posaconazole), and implementing antifungal stewardship programs are imperative in CAM cases.
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spelling pubmed-99774802023-03-02 A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM) Osman, Nermin A. Anwar, Mohammed Moustapha Singh, Bivek Gupta, Girish K. Rabie, Amgad M. J Egypt Public Health Assoc Review Coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) is responsible for a high mortality rate due to its unique and severe host-pathogen interactions. Critically ill or immunocompromised COVID-19 patients are more prone to suffer from aggressive mycoses. Probable victims include those with uncontrolled diabetes mellitus (DM), metabolic acidosis, prolonged neutropenia, increased ferritin levels, hypoxia, and prolonged hospitalization with/without mechanical ventilators and corticosteroids administration. The current review aims to outline the journey of patients with CAM as well as the advantages and disadvantages of the currently available diagnostic techniques. It also discussed the current status of treatment options and caveats in the management of mucormycosis. Multidisciplinary team, early diagnosis, controlling the predisposing condition(s), complete surgical debridement, effective antifungal therapies (e.g., amphotericin B, isavuconazole, and posaconazole), and implementing antifungal stewardship programs are imperative in CAM cases. Springer Berlin Heidelberg 2023-03-02 /pmc/articles/PMC9977480/ /pubmed/36859556 http://dx.doi.org/10.1186/s42506-022-00125-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Osman, Nermin A.
Anwar, Mohammed Moustapha
Singh, Bivek
Gupta, Girish K.
Rabie, Amgad M.
A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title_full A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title_fullStr A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title_full_unstemmed A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title_short A peek behind the curtain in the diagnosis and management of COVID‑19‑Associated Mucormycosis (CAM)
title_sort peek behind the curtain in the diagnosis and management of covid‑19‑associated mucormycosis (cam)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977480/
https://www.ncbi.nlm.nih.gov/pubmed/36859556
http://dx.doi.org/10.1186/s42506-022-00125-1
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