PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease

A GWAS of patients with anti-neutrophil cytoplasmic antibodies (ANCAs) found an association between proteinase-3 ANCA (PR3-ANCA) and a single nucleotide polymorphism (rs62132293) upstream of PRTN3, encoding PR3. The variant (G allele) was shown to be an expression quantitative trait locus in healthy...

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Detalles Bibliográficos
Autores principales: Chen, Dhruti P., Aiello, Claudia P., McCoy, DeMoris, Stamey, Taylor, Yang, Jiajin, Hogan, Susan L., Hu, Yichun, Derebail, Vimal K., Wu, Eveline Y., Jennette, J. Charles, Falk, Ronald J., Ciavatta, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977496/
https://www.ncbi.nlm.nih.gov/pubmed/36626226
http://dx.doi.org/10.1172/jci.insight.166107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977496/
https://www.ncbi.nlm.nih.gov/pubmed/36626226
http://dx.doi.org/10.1172/jci.insight.166107

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