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Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4
Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of d...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977501/ https://www.ncbi.nlm.nih.gov/pubmed/36810253 http://dx.doi.org/10.1172/jci.insight.166655 |
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author | Li, Zhuang Zhou, Enchen Liu, Cong Wicks, Hope Yildiz, Sena Razack, Farhana Ying, Zhixiong Kooijman, Sander Koonen, Debby P.Y. Heijink, Marieke Kostidis, Sarantos Giera, Martin Sanders, Ingrid M.J.G. Kuijper, Ed J. Smits, Wiep Klaas van Dijk, Ko Willems Rensen, Patrick C.N. Wang, Yanan |
author_facet | Li, Zhuang Zhou, Enchen Liu, Cong Wicks, Hope Yildiz, Sena Razack, Farhana Ying, Zhixiong Kooijman, Sander Koonen, Debby P.Y. Heijink, Marieke Kostidis, Sarantos Giera, Martin Sanders, Ingrid M.J.G. Kuijper, Ed J. Smits, Wiep Klaas van Dijk, Ko Willems Rensen, Patrick C.N. Wang, Yanan |
author_sort | Li, Zhuang |
collection | PubMed |
description | Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of dietary butyrate. We performed antibiotic-induced microbiota depletion of the gut and fecal microbiota transplantation (FMT) in APOE*3-Leiden.CETP mice, a well-established translational model for developing human-like metabolic syndrome, and revealed that dietary butyrate reduced appetite and ameliorated high-fat diet–induced (HFD-induced) weight gain dependent on the presence of gut microbiota. FMT from butyrate-treated lean donor mice, but not butyrate-treated obese donor mice, into gut microbiota–depleted recipient mice reduced food intake, attenuated HFD-induced weight gain, and improved insulin resistance. 16S rRNA and metagenomic sequencing on cecal bacterial DNA of recipient mice implied that these effects were accompanied by the selective proliferation of Lachnospiraceae bacterium 28-4 in the gut as induced by butyrate. Collectively, our findings reveal a crucial role of gut microbiota in the beneficial metabolic effects of dietary butyrate as strongly associated with the abundance of Lachnospiraceae bacterium 28-4. |
format | Online Article Text |
id | pubmed-9977501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-99775012023-03-02 Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 Li, Zhuang Zhou, Enchen Liu, Cong Wicks, Hope Yildiz, Sena Razack, Farhana Ying, Zhixiong Kooijman, Sander Koonen, Debby P.Y. Heijink, Marieke Kostidis, Sarantos Giera, Martin Sanders, Ingrid M.J.G. Kuijper, Ed J. Smits, Wiep Klaas van Dijk, Ko Willems Rensen, Patrick C.N. Wang, Yanan JCI Insight Research Article Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of dietary butyrate. We performed antibiotic-induced microbiota depletion of the gut and fecal microbiota transplantation (FMT) in APOE*3-Leiden.CETP mice, a well-established translational model for developing human-like metabolic syndrome, and revealed that dietary butyrate reduced appetite and ameliorated high-fat diet–induced (HFD-induced) weight gain dependent on the presence of gut microbiota. FMT from butyrate-treated lean donor mice, but not butyrate-treated obese donor mice, into gut microbiota–depleted recipient mice reduced food intake, attenuated HFD-induced weight gain, and improved insulin resistance. 16S rRNA and metagenomic sequencing on cecal bacterial DNA of recipient mice implied that these effects were accompanied by the selective proliferation of Lachnospiraceae bacterium 28-4 in the gut as induced by butyrate. Collectively, our findings reveal a crucial role of gut microbiota in the beneficial metabolic effects of dietary butyrate as strongly associated with the abundance of Lachnospiraceae bacterium 28-4. American Society for Clinical Investigation 2023-02-22 /pmc/articles/PMC9977501/ /pubmed/36810253 http://dx.doi.org/10.1172/jci.insight.166655 Text en © 2023 Li et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Li, Zhuang Zhou, Enchen Liu, Cong Wicks, Hope Yildiz, Sena Razack, Farhana Ying, Zhixiong Kooijman, Sander Koonen, Debby P.Y. Heijink, Marieke Kostidis, Sarantos Giera, Martin Sanders, Ingrid M.J.G. Kuijper, Ed J. Smits, Wiep Klaas van Dijk, Ko Willems Rensen, Patrick C.N. Wang, Yanan Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title | Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title_full | Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title_fullStr | Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title_full_unstemmed | Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title_short | Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4 |
title_sort | dietary butyrate ameliorates metabolic health associated with selective proliferation of gut lachnospiraceae bacterium 28-4 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977501/ https://www.ncbi.nlm.nih.gov/pubmed/36810253 http://dx.doi.org/10.1172/jci.insight.166655 |
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