TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced lipotoxicity in the kidney

Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. However, the regulatory factors involved in countering...

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Detalles Bibliográficos
Autores principales: Nakamura, Jun, Yamamoto, Takeshi, Takabatake, Yoshitsugu, Namba-Hamano, Tomoko, Minami, Satoshi, Takahashi, Atsushi, Matsuda, Jun, Sakai, Shinsuke, Yonishi, Hiroaki, Maeda, Shihomi, Matsui, Sho, Matsui, Isao, Hamano, Takayuki, Takahashi, Masatomo, Goto, Maiko, Izumi, Yoshihiro, Bamba, Takeshi, Sasai, Miwa, Yamamoto, Masahiro, Matsusaka, Taiji, Niimura, Fumio, Yanagita, Motoko, Nakamura, Shuhei, Yoshimori, Tamotsu, Ballabio, Andrea, Isaka, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977505/
https://www.ncbi.nlm.nih.gov/pubmed/36649084
http://dx.doi.org/10.1172/jci.insight.162498

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