Cargando…

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24(−/−) Progeria Mouse Model

Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these conditions are limited and none target fundamental drivers of pathology, and thus identifying strategies to delay progressive loss of tissue homeostasis and functional reserv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hambright, William S., Mu, Xiaodong, Gao, Xueqin, Guo, Ping, Kawakami, Yohei, Mitchell, John, Mullen, Michael, Nelson, Anna-Laura, Bahney, Chelsea, Nishimura, Haruki, Hellwinkel, Justin, Eck, Andrew, Huard, Johnny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977556/ https://www.ncbi.nlm.nih.gov/pubmed/36875869 http://dx.doi.org/10.1155/2023/5572754

Ejemplares similares

Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells
por: Liu, Lei, et al.
Publicado: (2022)

Cellular expansion of MSCs: Shifting the regenerative potential
por: Miclau, Katherine, et al.
Publicado: (2022)

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells
por: Mullen, Michael, et al.
Publicado: (2023)

Paper 40: Improved Cartilage Healing with Microfracture Augmented with Fisetin & Bone Marrow Aspirate Concentrate in Acute Osteochondral Defect
por: Gao, Xueqin, et al.
Publicado: (2022)

Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency
por: Yao, Haidong, et al.
Publicado: (2020)

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle
por: Liu, Lei, et al.
Publicado: (2022)

Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration
por: Song, Minjung, et al.
Publicado: (2013)

Fisetin for COVID‐19 in skilled nursing facilities: Senolytic trials in the COVID era
por: Verdoorn, Brandon P., et al.
Publicado: (2021)

Sustained-release losartan from peptide nanofibers promotes chondrogenesis
por: Yamaura, Kohei, et al.
Publicado: (2023)

Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep
por: Huard, Charles A., et al.
Publicado: (2023)

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
por: Mu, Xiaodong, et al.
Publicado: (2020)

Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability
por: Kong, Keyu, et al.
Publicado: (2023)

Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
por: Barrowman, Jemima, et al.
Publicado: (2012)

ZMPSTE24 defends against influenza and other pathogenic viruses
por: Fu, Bishi, et al.
Publicado: (2017)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
por: Messner, Moritz, et al.
Publicado: (2020)

Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation
por: Lucas‐Herald, Angela K, et al.
Publicado: (2018)

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24
por: Babatz, Timothy D., et al.
Publicado: (2020)

Poster 217: Local and Systemic Comparison of Senescent Profiles in Acute Knee Injury
por: Whitney, Kaitlyn, et al.
Publicado: (2022)

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
por: Wu, Yuhao, et al.
Publicado: (2022)

Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence
por: O’hara, Kelsey, et al.
Publicado: (2022)

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
por: Lavasani, Mitra, et al.
Publicado: (2012)

Rapamycin for aging stem cells
por: Hambright, William S., et al.
Publicado: (2020)

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide
por: Akinci, Baris, et al.
Publicado: (2017)

Paradoxes of senolytics
por: Blagosklonny, Mikhail V.
Publicado: (2018)

Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan
por: Campisi, Judith
Publicado: (2020)

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24
por: Wood, Kaitlin M., et al.
Publicado: (2020)

Progeria
Publicado: (1935)

A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
por: Galant, Damien, et al.
Publicado: (2016)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24
por: Mehmood, Shahid, et al.
Publicado: (2016)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
por: Spear, Eric D., et al.
Publicado: (2018)

Accelerated aging induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis
por: Calyeca, Jazmín, et al.
Publicado: (2018)

ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1
por: Han, Mingming, et al.
Publicado: (2021)

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice
por: Wang, Yuexia, et al.
Publicado: (2022)

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity
por: Stott-Marshall, Robert J., et al.
Publicado: (2022)

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
por: Suo, Jinlong, et al.
Publicado: (2023)

Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration
por: Nelson, Anna Laura, et al.
Publicado: (2022)

Living with Progeria
por: Stamsnijder, Marjet
Publicado: (2010)

New Perspectives for Fisetin
por: Grynkiewicz, Grzegorz, et al.
Publicado: (2019)

Fisetin: An anticancer perspective
por: Imran, Muhammad, et al.
Publicado: (2020)

The curcumin analog EF24 is a novel senolytic agent
por: Li, Wen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_io0f0f3onr3an7jshqq6t94r19